Pharmaceutical Applications of Raman Spectroscopy

Carefully organized with an emphasis on industry issues, Pharmaceutical Applications of Raman Spectroscopy provides the basic theory of Raman effect and instrumentation and then addresses a wide range of pharmaceutical applications. Current applications that are routinely used as well as those with promising potential are covered Applications cover a broad range from discovery to manufacturing in the pharmaceutical industry and include identifying polymorphs, monitoring real-time processes, imaging solid dosage formulations, imaging active pharmaceutical ingredients in cells and diagnostics.

 

• Introduction to Raman Spectroscopy (Yukihiro Ozaki and Slobodan Sasic)
• Quantitative Analysis of Solid Dosage Formulations by Raman Spectroscopy (Steven EJBell)
• Surface Enhanced Resonance Raman Scattering (W. Ewen Smith)
• Raman Spectroscopy for Identifying Polymorphs (Fred Laplant and Anne De Paepe)
• Raman Spectroscopy for Monitoring Real-time Processes in the Pharmaceutical Industry (Kevin L. Davis, Mark S. Kemper and Ian R. Lewis)
• Raman Chemical Imaging of Solid Dosage Formulations (Slobodan Sasic)
• In vivo Raman Confocal Microspectroscopy of Skin (Andre van der Pol, William M Riggs and Peter J. Casper’s)
• Raman Microspectrscopy and Imaging of Active Pharmaceutical Ingredients in Cells (Jian Ling)

 

Table of Contents:

Preface

Contributors

Introduction to Raman Spectroscopy (Yukihiro Ozaki and Slobodan Sasic)

 

• History of Raman Spectroscopy
• The Principle of Raman Spectroscopy
• An Example of Simple Raman Spectrum: Raman Spectrum of Water
• Characteristics of Raman Spectroscopy
• The Classic Theory of Raman Effect
• The Quantum Theory of Raman Scattering
• Cross Section
• Relevance to Pharmaceuticals
• Resonance Raman Effect
• Instrumentation for Raman Spectroscopy

 

Quantitative Analysis of Solid Dosage Formulations by Raman Spectroscopy (Steven EJBell)

 

• Introduction
• Quantitative Analysis
• Instrumental Parameters
• Experimental Considerations
• Nonstandard Samples
• Conclusions

 

Surface Enhanced Resonance Raman Scattering (W. Ewen Smith)

 

• Theory
• The Experimental Setup
• Examples of SERS/SERRS Assays

 

Raman Spectroscopy for Identifying Polymorphs (Fred Laplant and Anne De Paepe)

 

• Introduction of Polymorphism
• Instrumental Methods of Polymorph Characterization
• Polymorph Screening
• Process Control
• Polymorph Quantitation
• Calibration Set and Sample Preparation
• Quantitation
• Intellectual Property

 

Raman Spectroscopy for Monitoring Real-time Processes in the Pharmaceutical Industry (Kevin L. Davis, Mark S. Kemper and Ian R. Lewis)

 

• Introduction
• A Brief History of Raman Spectroscopy
• Basic Theory of Raman Spectroscopy
• General Instrumentation for Raman Spectroscopy
• The Choice-Dispersive or FT
• Process Analysis and PAT
• Why choose Raman as a PAT Tool? The Need for Raman
• Data Analysis
• Applications
• Conclusions

 

Raman Chemical Imaging of Solid Dosage Formulations (Slobodan Sasic)

 

• Methods for Chemical Imaging
• Data Analysis
• Experimental
• Applications

 

In vivo Raman Confocal Micro spectroscopy of Skin (Andre Van Der Pol, William M. Riggs and Peter J. Casper’s)

 

• Introduction
• Applications
• Summary and Discussion

 

Raman Microspectrscopy and Imaging of Active Pharmaceutical Ingredients in Cells (Jian Ling)

 

• Introduction
• Current Approaches to Drug Imaging
• Raman Spectroscopy and Raman Imaging
• Raman Micro spectroscopy and Imaging for Drug Research
• Raman Intensity, Fluorescence Background and SNR
• Techniques to Improve SNR in Raman Imaging
• Enhanced Raman Images with Postprocessing
• Raman Imaging of Intracellular Distribution of Paclitaxel in Living Cells
• Raman Imaging of Intracellular Distribution of Sulindac Sulfide in Fixed Cells
• Conclusions and Future Outlook.